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EXECUTIVE SUMMARY
Pages 1-8

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From page 1...
... to establish national drinicing ~ water standards for chemical and biological contaminants in public water supplies. The standards are to be set at concentrations at which no adverse effects on human health occur or are expected to occur from lifetime consumption, allowing a margin of safety; enforceable standards are stanciarcis that are feasible to achieve with the use of the best technology available.
From page 2...
... MethemogIobinemia in adults is rare; most methemogIobinemia victims are infants who have been fed formula mixed with nitrate-containing well water or food with a high nitrate content or who have diarrhea. Results of epidemiologic studies are inadequate to support an association between high nitrate or nitrite exposure from drinI
From page 3...
... A discussion of close-response relationships between human carcinogenesis and nitrate or nitrite exposure is not appropriate without supporting epidemiologic data and a physiologically based pharmacoIcinetic mode! that would permit analysis of the complex relationships between exogenous and endogenously formed nitrate, nitrite, and N-nitrosamines.
From page 4...
... A previous Natinal Research Council report on the health effects of nitrate, nitrite, and N-nitroso compounds concluded that for more than 99% of the U.S. population, about 97% of nitrate intake comes from the diet (99% in the case of vegetarians)
From page 5...
... . The subcommittee concluded that exposure to the nitrate concentrations found in drinking water in the United States is unlikely to contribute to human cancer risk.
From page 6...
... Regulating exogenous nitrate exposure on the basis of carcinogenicity wouIcT also be inconsistent with endogenous nitrate formation. Available data are inadequate to support an association between nitrate and nitrite exposure from drinking water and any noncancer effects except for methemoglobinemia in infants, which might occur as a result of exposure to nitrate-contaminated water or to vegetables with high concentrations of nitrate or as a result of increased endogenous nitrate synthesis in cases of infection.
From page 7...
... Nitrate an) Nitrite in Drinking Water


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