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B GRADE Grid Template 253
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Sleep (unrefreshing sleep, sleep disturbance/ dysfunction) Neurocognitive manifestations (mental fatigue, memory impairment, concentration difficulties, confusion)
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Balance between desirable and undesirable effects of inclusion as a required or core symptom or symptom category Desirable consequence: The specific symptom or symptom category is present in a majority of ME/CFS patients, and its inclusion as a required symptom could prevent incorrect diagnoses of ME/CFS in those that do not have it. Undesirable consequence: The specific symptom or symptom category is not present in a majority of ME/CFS patients, and its requirement could thus exclude patients with ME/CFS from diagnosis.
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Key Terms
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